Pharmacodynamic synthesis of cube containing bradiquinia and acido hiarronic

摘要

It refers to a polymer containing (a) 1 mg to 1000 mg of polyurethane or its Na and K salts in the composition; and (b) an antagonist to bradykinin receptor B2, such as a derivative of formula compound (I).R is h, or CH3; W is simple link or O; X is h, or Amin nr1r2 group; R1 and R2 are h, CH3, isopropyl, etc.; and are quaternary ammonia (- nr3r4r5) + a -;Among them, R3, R4 and R5 are CH3, ethyl and n-propyl, respectively; n is 3 or 4, with the content ranging from 0.05 mg to 20 mg. This combination is an effective synergistic combination in the treatment of degenerative joint diseases such as osteoarthritis. It can also be a preparation method for injection solution preparation, gel or patch management, via in-line, embedded or filter