Combination of drugs for the treatment of dushanne muscular atrophy

摘要

REFERRED TO A COMBINATION CONSISTING OF: A) A SELECTED AUXILIARY AGENT AMONG ANTI-INFLAMMATORY AGENT, PROTEASE INHIBITOR, CYTOKINE OR MOBILIZING AGENT, AMONG OTHERS; B) A COMPOUND OF FORMULA I, WHERE A1, A2, A3 AND A4 ARE EACH N, CR1; R1 IS HYDROXYL, ARYL, NO2, AMONG OTHERS; X ES O, S (O) n, C = W, NR4, NC (= O) R5, CR6R7; W ES O, S, NR20; Y IS N, CR8; R4, R5, R6, R8, R9 AND NR20 ARE EACH -L-R3; L IS A LINK OR BRIDGE GROUP; R3 IS H, THIOARYL, ALKYL, ALCOXY, AMONG OTHERS; n IS 0-2. SUCH COMBINATION IS USEFUL IN THE THERAPEUTIC AND / OR PROPHYLACTIC TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY, MUSCULAR DISTROPHIS OF BECKER, CAQUEXIA