SCREENING FOR PEPTIDES INHIBITING PP1C BINDING TO BCL-2, BCL-XL AND BCL-W PROTEINS

摘要

The invention relates to methods for identifying novel PP1-interacting polypeptides and proteins, compounds which are able to inhibit the binding of PP1c to certain factors naturally interacting with it, especially proteins of the Bcl-2 family (such as Bcl-XL and Bcl-w), and pharmaceutical compositions comprising the same. The invention is based on the identification of a new PP1- binding motif having the sequence FXXÄRKÜXÄRKÜ, wherein X is any amino acid.