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DERIVATIVES OF N-/PHENYL(PYRROLIDINE-2-YL) METHYL/BENZAMIDE, AND N- /(AZEPAN-2-YL)PHENYLMETHYL/BENZAMIDE, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS
DERIVATIVES OF N-/PHENYL(PYRROLIDINE-2-YL) METHYL/BENZAMIDE, AND N- /(AZEPAN-2-YL)PHENYLMETHYL/BENZAMIDE, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS
The invention relates to compounds having general formula (I), wherein: n represents the number 1 or 3; R1 represents either H or a cycloalkyl, cycloalkylalkyl, phenylalkyl, alkenyl, alkynyl group; X represents either H or one or more substituents selected from among halogen atoms and the trifluoromethyl, alkyl and alkoxy groups; and R2 represents H, or one or more substituents selected from among the halogen atoms and the trifluoromethyl, alkyl, alkoxy, cycloalkyl, phenyl, cyano, acetyl, benzoyl, S-alkyl, alkyl-sulfonyl, carboxy and alkoxycarbonyl groups, or a group having formula NR3R4, SO2NR3R4 or CONR3R4, in which R3 and R4 each represent H or an alkyl or cycloalkyl group or, together with the nitrogen atom, form a pyrrolidine, piperidine or morpholine ring. The invention also relates to the use of said compounds in therapeutics.
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机译:本发明涉及具有通式(I)的化合物,其中:n代表数字1或3; R1代表H或环烷基,环烷基烷基,苯基烷基,烯基,炔基; X代表H或一个或多个选自卤素原子和三氟甲基,烷基和烷氧基的取代基; R 2表示H,或选自卤素原子和三氟甲基,烷基,烷氧基,环烷基,苯基,氰基,乙酰基,苯甲酰基,S-烷基,烷基磺酰基,羧基和烷氧羰基中的一个或多个取代基或基团具有式NR3R4,SO2NR3R4或CONR3R4的化合物,其中R3和R4各自代表H或烷基或环烷基,或与氮原子一起形成吡咯烷,哌啶或吗啉环。本发明还涉及所述化合物在治疗中的用途。
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