new derivatives ureici acid 1h - pirazol - 4 - carboxylic with inhibitory activity against the chemiotassi of neutrophils

摘要

Compounds of formula (I), wherein R 1 = H, optionally substituted C 1 -C 8 alkyl, -CH 2 -CH(R 3 )OR 2 , where R 2 = H or C 1 -C 3 alkyl and R 3 = optionally substituted C 1 -C 8 alkyl; Q = NHR 4 or a saturated heterocyclic 3-7 membered ring containing nitrogen, where R 4 = optionally substituted C 3 -C 8 alkyl, optionally substituted aralkyl, optionally substituted aryl; and enantiomers, diastereoisomers and pharmaceutically acceptable salts thereof; it is also described a process for preparing such compounds, the use of such compounds as a medicament, in particular in the treatment of inflammatory diseases of autoimmune origin, as well as pharmaceutical compositions that comprise such compounds.