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REDUCING VIRULENCE OF MYCOBACTERIUM TUBERCULOSIS AND TUBERCULOSIS PROTECTION BY INACTIVATING THE PHOP GENE
REDUCING VIRULENCE OF MYCOBACTERIUM TUBERCULOSIS AND TUBERCULOSIS PROTECTION BY INACTIVATING THE PHOP GENE
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机译:通过使噬菌体基因失活来降低结核分枝杆菌的毒力和结核分枝杆菌的保护
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摘要
The construction of a mutant in the phoP gene by means of homologous recombination from clinically isolated Mycobacterium tuberculosis reduces the virulence thereof in mouse bone marrow macrophage. Moreover, the phoP mutant reduces the virulence thereof in the experimental mouse model. Said phoP mutant can persist without being eliminated both in the macrophage and in the mouse. Mice inoculated with the phoP mutant are protected against M.tuberculosis infection. The use of mutants of mycobacteria in which the phoP gene or the genes regulated by phoP have been inactivated are candidates for vaccines against human and animal tuberculosis as well as possible recombinant vaccines against other pathogens.
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