USE OF 2,5-DIHYDROXYBENZOLSULPHONIC ACID DERIVATIVES IN THE PREPARATION OF A MEDICAMENT FOR INCREASING THE EFFECT OF OTHER MEDICAMENTS FOR TREATING THE EFFECTIVE DYSFUNCTION

摘要

Use of 2,5-dihydroxy-benzenesulfonic (or 1,4-disulfonic) acid calcium or diethylammonium salts (I) for potentiating the effect of agents (II) for stimulating penile erection in humans. Use of 2,5-dihydroxy-benzenesulfonic acid derivatives of formula (I) in the production of a medicament for potentiating the effect of agents (II) for stimulating penile erection in humans, where (II) are selected from phosphodiesterase V inhibitors, apomorphine, nitrogen monoxide donors, agents for increasing cyclic guanosine monophosphate (cGMP) levels in penile tissue and other agents for this purpose. [Image] R : H or DSO 3 -; A : Ca 2 + or N +H 2Et 2; and n, m : 1 or 2. ACTIVITY : Vasotropic. In isolated human corpus cavernosum, calcium dobesilate (Ia) at a concentration of 10 mu M significantly increased the relaxation of resistant arteries produced by specific concentrations of the phosphodiesterase inhibitor sildenafil (IIa). The relaxation was ca. 25% in presence of 10 nM (IIa) alone and ca. 65% in presence of 10 nM (IIa) and 10 mu M (Ia). MECHANISM OF ACTION : Promotion of relaxation of resistant arteries in the penis.