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BENZO 1,2,5 OXADIAZOLE AND BENZO 1,2,5 THIADIAZOLE AS HISTOPATHOLOGIC ADHESIVES, ILLUSTRATORS AND BIOMARKERS
BENZO 1,2,5 OXADIAZOLE AND BENZO 1,2,5 THIADIAZOLE AS HISTOPATHOLOGIC ADHESIVES, ILLUSTRATORS AND BIOMARKERS
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机译:1,2,5恶二唑和1,2,5噻二唑用作组织病理学粘合剂,插画和生物标志物
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摘要
The present invention relates to novel benzo[1,2,5]oxadiazoles and benzo[1,2,5]thiadiazoles of formula (I) wherein X is O or S, R1 is 5-(2-fluoro-ethylamino)-thiazol-2-yl, 5-(2-18F-ethylamino)-thiazol-2-yl or a group of formula (a) wherein Y is CH or N, R2 is NHCH3, NH11CH3, N(CH3)11CH3, N(CH3)2, N(11CH3)2, NH(CH2)nF, NH(CH2)n18F, N(CH3)(CH2)nF, N(CH3)-(CH2)n18F, O-(CH2)nF, O-(CH2)n18F, CONH(CH2)nF or CONH(CH2)n18F (n being in each case 2 to 4) and R3 is hydroxy, (C1-4)alkoxy, hydrogen or nitro, in free base or acid addition salt form; their preparation, their use as markers in diagnosis and compositions containing them.
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