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VACCINE AGAINST YERSINIA WITH ONE OR TWO MONOCLONAL ANTIBODIES SPECIFIC TO YERSINIA PESTIS F1 ANTIGEN AND V-ANTIGEN

机译：针对耶尔森氏菌的疫苗，其中含有一种或两种针对耶尔森氏菌F1抗原和V-抗原的单克隆抗体

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摘要

The use of (i) an antibody specific for Yersinia pestis F1-antigen, or a binding fragment thereof, or (ii) an antibody specific for Yersinia pestis V-antigen, or a binding fragment thereof, or a combination of (i) and (ii), in the production of a medicament for the treatment of infection by Yersinia pestis. It has been found that such treatments are effective therapies for Yersinia pestis infection. In addition, the combination produces a synergistic effect when used prophylactically.

机译：（i）鼠疫耶尔森氏菌F1抗原特异的抗体或其结合片段或（ii）鼠疫耶尔森氏菌V抗原特异的抗体或其结合片段或（i）和（ii）在生产用于治疗鼠疫耶尔森氏菌感染的药物中。已经发现这种治疗是鼠疫耶尔森氏菌感染的有效疗法。另外，该组合在预防性使用时产生协同作用。

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公开/公告号AT435032T

专利类型
公开/公告日2009-07-15

原文格式PDF
申请/专利权人 THE SECRETARY OF STATE FOR DEFENCE;
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申请/专利号AT20030791048T
发明设计人 HILL JAMES;WILLIAMSON ETHEL DIANE;TITBALL RICHARD WILLIAM;
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申请日2003-08-29
分类号A61K39/40;A61P31/04;C07K16/12;
国家 AT
入库时间 2022-08-21 19:24:25

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2. Assessment of Comparative Genomic Hybridization Experiment by an in situ Synthesized CombiMatrix Microarray with Yersinia pestis Vaccine Strain EV76 DNA [J] . YUAN-HAI YOU, PENG WANG, YAN-HUA WANG, 生物医学与环境科学：英文版 . 2010,第005期

3. Assessment of Comparative Genomic Hybridization Experiment by an in situ Synthesized CombiMatrix Microarray with Yersinia pestis Vaccine Strain EV76 DNA [J] . YUAN-HAI YOU, PENG WANG, YAN-HUA WANG, 生物医学与环境科学（英文版） . 2010,第005期

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5. Synergistic Protection of Mice against Plague with Monoclonal Antibodies Specific for the F1 and V Antigens of Yersinia pestis [J] . Jim Hill, Catherine Copse, Sophie Leary, Infection and immunity . 2003,第4期

6. Concomitant administration of Yersinia pestis specific monoclonal antibodies with plague vaccine has a detrimental effect on vaccine mediated immunity [J] . Eyles JE, Butcher WA, Titball RW, Vaccine . 2007,第42期

7. Effect of serotonin on the expression of antigens and DNA levels in Yersinia pestis cells with different plasmid content [C] . S. N. Klueva, V. N. Korsukov, T. N. Schukovskaya, Conference on optical technologies in biophysics and medicine . 2004

8. Targeted delivery of antigens to follicular dendritic cells via a monoclonal antibody specific for complement receptor 2 on marginal zone B cells: Dynamics of delivery and applications towards vaccine development. [D] . Whipple, Emily Christine. 2006

9. Synergistic Protection of Mice against Plague with Monoclonal Antibodies Specific for the F1 and V Antigens of Yersinia pestis [O] . Jim Hill, Catherine Copse, Sophie Leary, 2003

10. Synergistic Protection of Mice against Plague with Monoclonal Antibodies Specific for the F1 and V Antigens of Yersinia pestis [O] . Hill, Jim, Copse, Catherine, Leary, Sophie, 2003

11. Enhancement of the Immune Response to the Yersinia Yersinia pestis F1-V Candidate Vaccine by CpG Oligonucleotides [R] . Amemiya, K. 2005

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