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ANTIKÍRPER FOR THE TREATMENT OF IMMUNE DISEASE

机译:ANTIKÍRPER治疗免疫性疾病

摘要

The invention provides the use of an antibody or antibody fragment which specifically binds a marker produced by or associated with a cell or tissue in an organ of interest, said antibody or antibody fragment being labelled with a radioisotope or with a magnetic resonance image enhancing agent capable of external detection, in the manufacture of a medicament for use in a method of imaging hypoplastic, anatomically displaced or ectopic cells or tissues in a mammalian subject by scintigraphic or magnetic resonance imaging, wherein the amount of the labelled antibody or antibody fragment is sufficient to permit a scintigraphic image or an enhanced magnetic resonance image of said organ to be obtained. Also provided is a kit for use in such methods.
机译:本发明提供了特异性结合由目标器官中的细胞或组织产生或与之相关的标志物的抗体或抗体片段的用途,所述抗体或抗体片段用放射性同位素或能够将其成像的磁共振图像增强剂标记。用于外部检测的方法,在制造用于通过闪烁显像或磁共振成像对哺乳动物受试者的发育不良,解剖上移位或异位的细胞或组织成像的方法的药物中,其中标记的抗体或抗体片段的量足以允许获得所述器官的闪烁图像或增强的磁共振图像。还提供了用于这种方法的试剂盒。

著录项

  • 公开/公告号AT441667T

    专利类型

  • 公开/公告日2009-09-15

    原文格式PDF

  • 申请/专利权人 IMMUNOMEDICS INC.;

    申请/专利号AT20030078022T

  • 发明设计人 GOLDENBERG MILTON DAVID;

    申请日1993-04-02

  • 分类号A61K49;C07K16/28;A61B5/05;A61B5/055;A61K39/395;A61K45;A61K47/48;A61K49/16;A61K51/04;A61K51/08;A61K51/10;A61P35;A61P37/06;A61P43;C07K;C07K16/18;C07K17;G01N33/53;G01R33/28;G01R33/48;

  • 国家 AT

  • 入库时间 2022-08-21 19:24:16

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