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METHOD FOR PRODUCING A COMPOSITION COMPRISING VENAFAXINE WITH PROGRAMMED RELEASE AND THE RESULTING PRODUCT
METHOD FOR PRODUCING A COMPOSITION COMPRISING VENAFAXINE WITH PROGRAMMED RELEASE AND THE RESULTING PRODUCT
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机译:含有文芬卡辛和程序释放的组合物的制备方法及其产物
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摘要
Process for the preparation of programmed liberation compositions with venlafaxine and the resulting product, from which the resulting product allows a better absorption of the active principle and a drastic decrease of the adverse effects, due to the preparation methodology. The formulation comprises a first phase, in which the non-active cores are elaborated as spherical micro granules, from sugar and starch. In the second phase, it is added to them the active drug, as impalpable powder, utilizing as binding, a povidone alcoholic solution. In the third phase, it is applied the coating on the micro granules that contain the active drug. At last, in the fourth phase, it is made the encapsulation of the recoated micro granule.
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