Peptidomimetic attached to a matrix as medicines against HIV and cancer.

摘要

Compounds of general formula: (See formula) wherein (see formula) is a group having one of the formulas D Pro L Pro and L-Pro-D Pro R 20 is H; I rent; alkenyl; or aryl-lower alkyl; R 32 is H; lower alkyl; or aryl-lower alkyl; R 33 is H; alkyl, alkenyl; - (CH2) m (CHR 61) SOR 55; - (CH2) m (CHR 61) R 63 snr 34; - (CH2) m (CHR 61) sOCONR 75 R 82; - (CH2) m (CHR 61) CONR 78 R 20 SnR 82; - (CH2) O (CHR 61) s, COR 64; - (CH2) O (CHR 61) s -CONR 58 R 59, - (CH2) O (CHR 61) SPO (OR 60) 2; - (CH2) o (CHR 61) sSO2R 62; or - (CH2) o (CHR 61) sC6H4R 8; R 34 is H; lower alkyl; aryl, or aryl lower alkyl; R 33 and R 34 together can form: - (CH2) 2 - 6; - (CH2) 2O (CH2) 2-; - (CH2) 2S (CH2) 2-; or - (CH2) 2NR 57 (CH2) 2-; R 37 is H; F; Br; Cl; NO2; CF3; lower alkyl; - (CH2) p (CHR 61) SOR 55; - (CH2) p (CHR 61) R 34 snr 33; - (CH2) p (CHR 61) s OCONR 33 R 75; - (CH2) p (CHR 61) CONR 33 R 20 SnR 12; - (CH2) o (CHR 61) CSYS 17; - (CH2) o (CHR 61) sCONR 58 R 59; - (CH2) o (CHR 61) SPO (OR 60) 2; - (CH2) o (CHR 61) sSO2R 62; or - (CH2) o (CHR 61) sC6H4R 8; R 50 is H; lower alkyl; or aryl-lower alkyl; R 55 is H; lower alkyl; lower alkenyl; aryl lower alkyl; - (CH2) m (CHR 61) SOR 57; - (CH2) m (CHR 61) s NR 34 R 63; - (CH2) m (CHR 61) sOCONR 75 R 82; - (CH2) m (CHR 61) CONR 78 R 20 SnR 82; - (CH2) O (CHR 61) s -COR 64; - (CH2) O (CHR 61) COOR 57; or - (CH2) O (CHR 61) sCONR 58 R 59; R 56 is H; lower alkyl; lower alkenyl; aryl lower alkyl; - (CH2) m (CHR 61) SOR 57; - (CH2) m (CHR 61) s NR 34 R 63; - (CH2) m (CHR 61) sOCONR 75 R 82; - (CH2) m (CHR 61) CONR 78 R 20 SnR 82; - (CH2) o (CHR 61) s -COR 64; or - (CH2) o (CHR 61) sCONR 58 R 59; R 57 is H; lower alkyl; lower alkenyl; aryl lower alkyl; or heteroaryl lower alkyl; R 58 is H; lower alkyl; lower alkenyl; aryl; heteroaryl; aryl lower alkyl; or heteroaryl-lower alkyl; R 59 is ...