Peptidomimetics attached to a matrix

摘要

Compounds of general formula in which it is DProLPro or LPro-DPro, and Z is a chain of 12 a-amino acid residues, counting the positions of said amino acid residues in said chain starting from the N-terminal of amino acid, so that these amino acid residues are found in positions P1 to P12 of the chain, - P1: Ala, Cit, Thr, Asp, Glu; - P2: Trp, Tyr; - P3: Ile, Val, Nle, Chg, Cha; - P4: Dab, Lys, Gln; - P5: Lys, Dab, Orn; - P6: Dab, DDab, Lys; - P7: His, Lys, Gln, Dab; - P8: Tyr, Trp, Ser; - P9: Dab, Lys; - P10: Dab, Lys; - P11: Ala, Abu, Thr, Gly, Pro, Hse, Ile, Nva, DAla, DVal, Aib, Nle, Chg, Cha, Gln, Asp, Glu, Cpa, t-BuG, Leu, Val, Asn; and - P12: Dab, Lys, Gln, Ser; and pharmaceutically acceptable salts thereof.