DERIVATIVES OF ADAMANTIL-PIRROLIDIN-2-ONA AS INHIBITORS DELA 11-BETA-HYDROXIESTEROID-DEHYDROGENASE.

摘要

A compound having the formula (See formula) the N-oxide forms, pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein n is 1 or 2; M represents a direct bond or a C1-3 alkyl linker optionally substituted with one or two substituents selected from C1-4 alkyl, C1-3 alkyloxyC1-4 alkyl, hydroxy C1-4 alkyl, hydroxy, C1- alkyloxy 3- or phenyl-C1-4 alkyl; R 1 and R 2 each independently represent hydrogen, halo, cyano, hydroxy, C 1-4 alkyl optionally substituted with halo, C 1-4 alkyloxy optionally substituted with one or, if possible, two or three hydroxy substituents, Ar 1 and halo; R 3 represents hydrogen, halo, C 1-4 alkyl, C 1-4 alkyloxy, cyano or hydroxy; R 4 represents hydrogen, halo, C 1-4 alkyl, hydroxy, cyano or C 1-4 alkyloxy optionally substituted with one or, if possible, two or three substituents selected from hydroxy and halo; R 5 represents hydrogen, C 1-4 alkyl or Ar 2 -C 1-4 alkyl; R 6 represents hydrogen, hydroxy, halo, C1-4 alkyl or C1-4 alkyloxy; R 7 represents hydrogen, or R 7 and R 5 considered together with the carbon atom to which they are attached, form a -C2-alkyl- linker; Ar 1 and Ar 2, each independently, represent phenyl or naphthyl, wherein said phenyl and naphthyl are optionally substituted with C 1-4 alkyl, C 1-4 alkyloxy, or phenyl C 1-4 alkyl.