RIPROXIMINE, AN INACTIVATING PROTEIN OF NOVEDOSE TYPE II RIBOSOMES AND USES OF THE MSIMA.

摘要

Nucleic acid molecule encoding the plant type II ribosome inactivating protein (RIP), riproximin, that exhibits antineoplastic activity, which is: (a) a nucleic acid molecule encoding a polypeptide comprising the amino acid sequence as depicted in figure 7 or figure 11 (SEQ ID NO: 3 or 4 or 6); (b) a nucleic acid molecule comprising the nucleotide sequence as depicted in Figure 6 (a) (SEQ ID NO: 1) or (b) (SEQ ID NO: 2) or in Figure 11 (SEQ ID NO: 5); (c) a nucleic acid molecule encoding a polypeptide whose sequence is at least 80% identical to the amino acid sequence of the polypeptide encoded by a nucleic acid molecule specified in (a) or (b); (d) a nucleic acid molecule whose sequence differs from the sequence of a nucleic acid molecule from (a) to (c) due to the degeneracy of the genetic code.