COMBINATION OF A TRANSDERMAL THERAPEUTIC SYSTEM AND AN ORAL AND / OR PARENTERAL PREPARATION CONTAINING DOPAMINERGIC AGONISTS FOR THE TREATMENT OF DOPAMINERGIC DISEASES.

摘要

Use of an ergoline derivative according to formula I or its physiologically compatible salt, (See formula) in which - - - - -________ is a single bond or a double bond, R1 is an H atom or a halogen atom, in particular a bromine atom, and R2 is a C1-4 alkyl, for the preparation of a means for the treatment of diseases of the group consisting of Morbus Parkinson, parkinsonism, restless legs syndrome and alterations of the dopaminergic system, characterized in that the medium is presented in at least two spatially separated forms, one of which contains the ergoline derivative in a transdermal therapeutic system (TTS) and one or more other forms contain the same ergoline derivative in a preparation arranged for parenteral dose and / or oral, and because the TTS is intended for continued application and the preparation prepared for parenteral and / or oral dose is planned for a discontinuous dose within the duration of application of the TTS.