ANTIMICROBIAL CATIONIC PEPTIDES AND SELECTION PROCEDURES OF THE SAME.

摘要

A NEW CLASS OF CATIONIC PEPTIDES THAT HAVE ANTIMICROBIAL ACTIVITY IS DISCOVERED. THESE PEPTIDES CAN BE UNDERSTANDED BY THE FORMULAS: X SUB, 1} X SUB, 1} PX SUB, 2} X SUB, 3} X SUB, 2} P (X SUB, 2} X SUB, 2} P) SUB, N} X SUB, 2} X SUB, 3} (X SUB, 5}) SUB, O} (SEQ ID NUM. 23); X SUB, 1} X SUB, 1} PX SUB, 2} X SUB, 3} X SUB, 4} (X SUB, 5}) SUB, R} PX SUB, 2} X SUB, 3} X SUB, 3 } (SEQ ID NUM. 24); X SUB, 1} X SUB, 1} X SUB, 3} (PW) SUB, U} X SUB, 3} X SUB, 2} X SUB, 5} XS UB, 2} X SUB, 2} X SUB, 5} X SUB, 2} (X SUB, 5}) SUB, 0} (SEQ ID NUM. 25); X SUB, 1} X SUB, 1} X SUB, 3} X SUB, 3} X SUB, 2} P (X SUB, 2} X SUB, 2} P) S UB, N} X SUB, 2} ( X SUB, 5}) SUB, M} SEQ ID NUM. 26; IN WHICH M IS FROM 1 TO 5; N ES 1 O 2; OR IS 2 TO 5; R ES 0 TO 8; U ES 0 TO 1; X SUB, 1} IS ISOLEUCINE, LEUCINE, VALINE, PHENYLALANINE, TYROSINE, TRIPTOPHAN OR METIONIN; X SUB, 2} REPRESENTS TRIPTOPHAN OR PHENYLALANINE; X SUB, 3} REPRESENTS ARGININA OR LISINA; X SUB, 4} REPRESENTS TRIPTOPHAN OR LISINE; AND X SUB, 5} REPRESENTS PHENYLALANINE, TRIPTOPHAN, ARGININE, LISINE OR PROLIN. THE INVENTION ALSO PROVIDES A METHOD TO PRODUCE VARIATIONS OF CATIONIC PEPTIDES WITH ANTIMICROBIAL ACTIVITY.