Controlled removal of a biological membrane using a pyrotechnic charge for transmembrane transport.

摘要

A device (10) to form at least one opening in a selected area of ​​a biological membrane for transmembrane transport, which device comprises: a) a substrate (20) having an upper surface (22), and a surface bottom (24); b) a pyrotechnic element (30) disposed on the lower surface of said substrate having an explosive potential sufficient to form such artificial opening pyrotechnic element; c) a trigger device (40) coupled to said pyrotechnic element; characterized in that: said substrate has at least one opening (26) extending through said substrate (20), each aperture having a perimeter wall, that said pyrotechnic element (40) is disposed on either the upper surface, or the lower surface of said next substrate to the opening (26), and that a portion of said pyrotechnic element (40) extends into said opening to form a surface defined charge separated a predetermined distance from the lower surface said substrate so that the shape, diameter and depth of the artificial opening is controlled.