IMPROVED METHODS AND REAGENTS FOR DIAGNOSIS AND TREATMENT OF DIABETES AND STIROME SYNDROME.

摘要

THE INVENTION PROVIDES FRAGMENTS OF GAD 65 WHICH ARE SPECIFICALLY REACTIVE WITH AT LEAST A GAD AUTOANTIBODY CLASS {SUB, 65}. MOST FRAGMENTS ARE SUBSTANTIALLY FREE OF N-TERMINAL AMINO ACIDS THAT WOULD OTHERWISE LIMIT SOLUBILITY. THE DIFFERENT FRAGMENTS CONTAIN EPITHOPES FOR THE DIFFERENT CLASSES OF ANTIBODIES GAD {SUB, 65}. THE ANTIBODIES ARE USED IN METHODS OF DIAGNOSIS AND TREATMENT OF THE DIABETIC MELLITUS DEPENDING ON THE INSULIN AND THE SYNTHROME OF STIFF MAN.