Improved reagents and methods for diagnosis and treatment of diabetes and stiff man syndrome

摘要

The invention provides fragments of GAD65 that are specifically reactive with at least one class of GAD65 autoantibody. Most fragments are substantially free of N-terminal amino acids that would otherwise limit solubility. Different fragment contain epitopes for different classes of GAD65 autoantibodies. The fragments are used in methods of diagnosing and treating insulin dependent diabetes mellitus and stiff man syndrome.