Use of inhibitors of filamine a protein activity, for the elaboration of pharmaceutical compositions, compounds inhibitors of such activity, pharmaceutical compositions and their therapeutic applications and procedure identification of such inhibitor compounds (Machine-translation by Google Translate, not legally binding)

摘要

Use of inhibitors of filamina a protein activity for the preparation of pharmaceutical compositions, compounds inhibitors of said activity, pharmaceutical compositions and their therapeutic applications and method of identifying said inhibitor compounds. The present invention describes for the first time the inducing activity of the hiv-1 infection of the filamine a protein (flna) as a regulator of the interactions of the cd4 protein and of the coreceptores cxcr4 and ccr5, thus becoming a therapeutic target. In addition, the domains of these regulatory proteins of said interactions have been identified, identifying inhibitory molecules thereof that can be used for the preparation of therapeutic compositions useful for the treatment and prevention of hiv-1 infection, among other diseases. Finally, flna can become the basis of a procedure for the identification of new compounds that inhibit hiv-1 infection. (Machine-translation by Google Translate, not legally binding)