ANTIMICROBIAL BOLISINE PEPTIDES.

摘要

Peptides with antimicrobial activity with the amino acid sequence in which R1- ZX3X3X1BX3RX2X3X4BRX2BX3X3B-R2, R1 are an amino group (NH2), an amino acid or a peptide with up to 10 amino acids and R2 COOH, CONH2, an amino acid or a peptide with up to 10 amino acids; Z an aromatic amino acid (W, Y, F), preferably tyrosine (Y); X1 arginine (R) or an aromatic amino acid (W, Y, F), preferably tryptophan (W); X 2 serine (S), a basic amino acid (R, K), preferably arginine (R), or an aromatic amino acid (W, Y, F), preferably tryptophan (W); X3 threonine (T), a hydrophobic amino acid (I, V, A, L) or arginine (R); X 4 aspartic acid (D), proline (P), a basic amino acid (K, R), preferably arginine (R), or an aromatic amino acid (W, Y, F), preferably tryptophan (W), and B an amino acid basic (K, R), as well as its derivatives and / or fragments with antimicrobial activity, especially the derivatives and / or amidated, acylated, acetylated, alkylated, sulphated, phosphorylated, halogenated fragments, especially halogenated in the aromatic side chains of amino acids, glycosylated, oxidized, modified by esterification or formation of lactone and / or cyclized, the peptides not comprising the amino acid sequence R 3-YIVYKIRSADKRSKALK-R 4, in which R 3 represents an amino group (NH 2), an amino acid or a peptide with up to 50 amino acids and R 4 COOH, CONH2, an amino acid or a peptide with up to 50 amino acids, as well as the amidated, acetylated, sulphated, phosphorylated, glycosylated, oxidized derivatives or fragments with derived antimicrobial properties of the amino acid sequence, in particular the fragments obtained by conservative substitution or amino acid deletion.