DERIVATIVES OF PROPANOIC ACID INHIBITING THE UNION OF INTEGRINS TO ITS RECEPTORS.

摘要

A compound selected from the group consisting of: (3S) -3 - {[(2S) -2- (3-benzyl-5-methyl-2-oxopyridin-1 (2H) -yl) hexanoyl] -amino} - 3- (3 '', 4 '' - dimethoxy-1-, 1 '' - biphenyl-4-yl) propanoic acid, (3S) -3 - ({(2S) -2- [3- (2-chlorobenzyl ) -5-methyl-2-oxopyridin-1 (2H) -yl] -hexanoyl} amino) -3- (3 '', 4 '' - dimethoxy-1,1''biphenyl-4-yl) propanoic acid, acid (3S) -3- (1,1 '' - biphenyl-4-yl) -3 - ({(2S) -2- [3- (2-chloro-6-methylbenzyl) -5-methyl-2-oxopyridin -1 (2H) -yl] hexanoyl} amino) propanoic acid, (3S) -3 - {[(2S) -2- (3-benzyl-5-methyl-2-oxopyridin-1 (2H) -yl) hexanoyl ] -amino} -3- (1,1 '' - biphenyl-4-yl) propanoic acid, (3S) -3- (1,1 '' - biphenyl-4-yl) -3 - ({(2S) -2- [3- (2-Chlorobenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] hexanoyl} amino) propanoic acid, (3S) -3 - {[(2S) -2- (3 -benzyl-5-methyl-2-oxopyridin-1 (2H) -yl) hexanoyl] -amino} -3- (4 '' - methyl-1,1 '' - biphenyl-4-yl) propanoic acid, (3S ) -3 - ({(2S) -2- [3- (2-Chlorobenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] -hexanoyl} amino) -3- (4 '' - methyl -1,1-biphenyl- 4-yl) propanoic acid, (3S) -3 - ({(2S) -2- [3- (2-chloro-6-methylbenzyl) -5-m ethyl-2-oxopyridin-1 (2H) -yl] hexanoyl} amino) -3- (4 '' - methyl- 1,1 '' - biphenyl-4-yl) propanoic acid, (3S) -3 - {[ (2S) -2- (3-Benzyl-5-methyl-2-oxopyridin-1 (2H) -yl) hexanoyl] -amino} -3- (2``, 6 '' - dimethoxy-1,1 '' -biphenyl-4-yl) propanoic acid, (3S) -3 - ({(2S) -2- [3- (2-chlorobenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] -hexanoyl} amino ) -3- (2``, 6 '' - dimethoxy-1,1''biphenyl-4-yl) propanoic acid, (3S) -3 - ({(2S) -2- [3- (2-chloro -6-methylbenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] hexanoyl} amino) -3- (2 '', 6 '' - dimethoxy-1,1 '' - biphenyl-4-yl ) propanoic acid (3S) -3 - {[(2S) -2- (3-benzyl-5-methyl-2-oxopyridin-1 (2H) -yl) hexanoyl] -amino} -3- (1,1 '' -biphenyl-3-yl) propanoic acid (3S) -3- (1,1 '' - biphenyl-3-yl) -3 - ({(2S) -2- [3- (2-chlorobenzyl- 5-methyl-2-oxopyridin- (2H) -yl] hexanoyl} amino) propanoic acid, (3S) -3- (1,1 '' - biphenyl-3-yl) -3 - ({(2S) -2 - [3- (2-Chloro-6-methylbenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] hexanoyl} amino) propanoic acid, (3S) -3 - [(2S) -2- ( 3-Benzyl-5-methyl-2-oxopyridin-1 (2H) -yl) hexanoyl] -amino} -3- (2 '' - methoxy-1,1 '' - biphenyl-3-yl) propanoic acid (3S) -3 - ({(2S) -2- [3- (2-Chlorobenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] -hexanoyl} amino) -3- (2 '' -methoxy-1,1 '' - biphenyl-3-yl) propanoic acid, (3S) -3 - ({(2S) -2- [3- (2-chloro-6-methylbenzyl) -5-methyl-2 -oxopyridin-1 (2H) -yl] hexanoyl} amino) -3- (2 '' - methoxy-1,1-biphenyl-3-yl) propanoic acid (3S) -3 - ({(2S) -2 - [3- (2-Fluoro-6-methoxybenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] hexanoyl} amino) -3- (4-methylphenyl) propanoic acid, (3S) -3- ({(2S) -2- [3- (2,6-Dimethylbenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] hexanoyl} amino) -3- (4-methylphenyl) propanoic acid, ( 3S) -3 - ({(2S) -2- [3- [3,5-dimethylbenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] -hexanoyl} amino) -3- (4- methylphenyl) propanoic acid, (3S) -3 - ({(2S) -2- [3- [2,6-dichlorobenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] hexanoyl} amino) - 3- (4-methylphenyl) propanoic acid, 39 null ES 2 321 059 T3 (3S) -3 - ({(2S) -2- [3- (2-chloro-6-fluorobenzyl) -5-methyl-2- oxopyridin-1 (2H) -yl] hexanoyl} amino) -3- (4-methylphenyl) propanoic acid (3S) -3 - ({(2S) -2- [3- (2,6-difluorobenzyl) -5 -methyl-2-oxopyridin-1 (2H) -yl] -hexanoyl} amino) -3- (4-methylphenyl) propanoic acid, (3S) -3- (1,3-benzodioxol-5-yl) -3 - ({(2S) -2- [3- (2,6-difluorobenzyl) -5-methyl -2-oxopyridin-1 (2H) -yl] hexanoyl} amino) propanoic acid, (3S) -3- (1,3-benzodioxol-5-yl) -3 - ({(2S) -2- [3- (2-Chloro-6-fluorobenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] hexanoyl} amino) propanoic acid, (3S) -3- (1,3-benzodioxol-5-yl) - 3 - ({(2S) -2- [3- [2,6-dichlorobenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] hexanoyl} amino) propanoic acid, (3S) -3- ( 1,3-benzodioxol-5-yl) -3 - ({(2S) -2- [3- (2,6-dimethylbenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] hexanoyl} amino ) propanoic acid (3S) -3- (1,3-benzodioxol-5-yl) -3 - ({(2S) -2- [3- (3,5-dimethylbenzyl) -5-methyl-2-oxopyridin -1 (2H) -yl] hexanoyl} amino) propanoic acid, (3S) -3- (1,3-benzodioxol-5-yl) -3 - ({(2S) -2- [3- (2-fluoro -6-methoxybenzyl) -5 methyl-2-oxopyridin-1 (2H) -yl] hexanoyl} amino) propanoic acid, (3S) -3 - ({(2S) -2- [3- (2-chlorobenzyl) - 5-methyl-2-oxopyridin-1 (2H) -yl] -hexanoyl} amino) -3- (3,4-diethoxyphenyl) propanoic acid (3S) -3- (3,4-diethoxyphenyl) -3- ( {(2S) -2- [3- (2,6-difluorobenzyl) -5-me til-2-oxopyridin-1 (2H) -yl] hexanoyl} amino) propanoic acid, (3S) -3 - ({(2S) -2- [3- (2,6-difluorobenzyl) -5-methyl-2 -oxopyridin-1 (2H) -yl] hexanoyl} amino) -3- (3-ethoxyphenyl) propanoic acid, (3S) -3 - ({(2S) -2- [3- (2-chloro-6-fluorobenzyl ) -5-methyl-2-oxopyridin-1 (2H) -yl] hexanoyl} amino) -3- (3-ethoxyphenyl) propanoic acid, (3S) -3 - ({(2S) -2- [3- ( 2-Chlorobenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] -3-methylbutanoyl} amino) -3- (4-methylphenyl) propanoic acid, (3S) -3 - ({(2S) - 2 [3- (2-Chlorobenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] -4-methylpentanoyl} -amino) -3- (4-methylphenyl) propanoic acid, (3S) -3- (1,3-benzodioxol-5-yl) -3 - ({(2S) -2- [3- (2-chlorobenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] -4-methylpentanoyl } amino) propanoic acid, (3S) -3- (1,3-benzodioxol-5-yl) -3 - ({(2S) -2- [3- (2-chlorobenzyl) -5-methyl-2-oxopyridine -1 (2H) -yl] -3-methylbutanoyl} amino) propanoic acid, (3S) -3- (1,3-benzodioxol-5-yl) -3 - ({(2S) -2- [3- ( 2-Chlorobenzyl) -5-methyl-2-oxopyridin-1 (2H) -yl] -3-phenylpropanoyl} amino) propanoic acid, (3S) -3 - ({(2S) -2- [3- (2- chlorobenzyl) -5-methyl- 2-oxopyridin-1 (2H) -yl] -3-phenylpropanoyl} amino) -3- (4-methylphenyl) propanoic acid, (3S) -3- (1,3-benzodioxol-5-yl) -3- ( ((2R) -2- (1-Benzyl-5-methyl-2-oxo-1,2-dihydropyridin-3-yl) hexanoyl) amino) propanoic acid, (3S) -3- (1,3-benzodioxol- 5-yl) -3 - (((2S) -2- (3-benzyl-5-methyl-2-oxo-1 (2H) pyridinyl) hexanoyl) amino) propanoic acid or one of its pharmaceutically acceptable salts.