PEPTIDES RECOGNIZED BY MELANOMA-SPECIFIC CYTOTOXIC LYMPHOCYTES, AND USES THEREFOR

摘要

Melanoma-specific CTL epitopes have been identified through improvements inthe art of identification of epitope-reconstituting peptides dissociated fromMHC Class I molecules on the surface of the tumor cells. Peptides homologouswith a segment of the melanoma/melanocyte antigen pMel-17 have proven to behighly potent stimulators of HLA-A2+CTL in several CTL cell lines. These andkindred peptides may be used to stimulate CTLs for use in adoptiveimmunotherapy, or incorporated into immunogenic conjugates for use as vaccines.