METHODS AND COMPOSITIONS FOR DETECTING DIHYDROPYRIMIDINE DEHYDROGENASE SPLICING MUTATIONS

摘要

The present invention provides compositions, methods and kits for thedetection of genetic polymorphisms or mutations relatedto dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphism ormutations generally occur in the dihydropyrimidinedehydrogenase DPD gene in chromosome 1. Also provided are mutant forms of DPD.