SUBSTITUTED BENZAMIDES FOR IMMUNE ENHANCEMENT AND FOR THE TREATMENT OF CANCER, INFECTION AND MANIC-DEPRESSIVE ILLNESS

摘要

This invention relates to the use of compounds of general formula (I) wherein,R is selected from methyl, ethyl, n-propyl, iso-propyl, c-propyl, n-butyl,sec.-butyl, iso-butyl, tert.-butyl, c-butyl, n-pentyl, sec.-pentyl, iso-pentyl, tert.pentyl, neo-pentyl, c-pentyl, c-hexyl and c-heptyl; RNa and RNbare the same or different and selected from hydrogen, methyl and ethyl; R2,R3, R5 and R6 are independently selected from hydrogen, methyl, methoxy,thiomethyl, hydroxy, fluoro, chloro, bromo, trifluoromethyl, phenyl andbenzyl; n is 1, 2 or 3; R' and R'' are the same or different and selected frommethyl, ethyl, n-propyl, iso-propyl,n-butyl, sec.-butyl, and iso-butyl or R'and R'' together form a saturated heterocyclic ring of 5-7 atoms is 1, 2, 3;and pharmaceutically acceptable salts, hydrates and solvates thereof; for thepreparation of a medicament for stimulation of transcription factor AP(activator protein)-1; compositions comprising the compounds of formula (I).The invention also comprises the compounds of general formula (I) with theexclusion of compounds wherein R, R' and R'' simultaneously are methyl. Thecompounds are useful for the treatment of cancer, infection and manic-depressive illness.