COLLAGEN SCAFFOLD MODIFIED BY COVALENT GRAFTING OF ADHESION MOLECULES: PROCESSES AND APPLICATIONS FOR CONTRACTILE TISSUE ENGINEEING, CELL THERAPY FOR THORACIC AND CARDIOVASCULAR

摘要

the present invention provides materials and methods for improving thebiological properties and performanceelectromechanical of collagen scaffolds used forcell transplantation. this is achieved by setting themedia and reagents through the setting of biocompatible moleculesto join, which control both the attachment of cells.apoptosis, survival, and differentiation. the linking of moleculesfor adhesion on collagen matrices leads to applicationsmedical / surgical and cardiothoracic and vascular therapyin the heart or cell for engineering aartificial heart. the invention also provides a simple method forbuild and optimize the presentation of peptidesmembership or if the biological scaffold is made of collagen and / orcontains amino acids accessible thiol groups.the carboxyl groups.