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Methods of determining a chemotherapeutic regimen based on loss of heterozygosity at the thymidylate synthase locus
Methods of determining a chemotherapeutic regimen based on loss of heterozygosity at the thymidylate synthase locus
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机译:根据胸苷酸合酶位点杂合性丧失确定化疗方案的方法
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摘要
The present invention is directed to a method of predicting a response to a chemotherapeutic regimen based on loss of heterozygosity at the thymidylate synthase locus in cancer tissue. This method comprises determining normal tissue genotype for thymidylate synthase of a patient; determining tumor tissue genotype for thymidylate synthase of said patient; comparing the normal tissue genotype with the tumor tissue genotype; determining whether a loss of heterozygosity at the thymidylate synthase locus has occurred in the tumor tissue based on the comparison of the genotypes; and predicting a response to the chemotherapeutic regimen based on the loss of heterozygosity in the tumor sample.
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