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ANTAGONIST PEPTIDES TO THE C5A CHEMOTACTIC FUNCTION OF VITAMIN D BINDING PROTEIN
ANTAGONIST PEPTIDES TO THE C5A CHEMOTACTIC FUNCTION OF VITAMIN D BINDING PROTEIN
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机译:维生素D结合蛋白C5A化学功能的拮抗剂
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摘要
It has been demonstrated that one of Vitamin D Binding Protein (DBP) biological functions is to enhance the chemotactic activity of C5a and C5a des Arg. The present invention has found that peptides having sequences that substantially correspond to a specific region in the N-terminal domain I of DBP can block the DBP enhancement of C5a or C5a des Arg chemotactic activity. Based in this discovery the present invention provides DBP antagonist peptides and the use thereof for the treatment C5a or C5a des Arg-mediated disorders.
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机译:已经证明维生素D结合蛋白(DBP)的生物学功能之一是增强C5a和C5a des Arg的趋化活性。本发明已经发现具有基本对应于DBP的N-末端结构域I中的特定区域的序列的肽可以阻断C5a或C5a des Arg趋化活性的DBP增强。基于该发现,本发明提供了DBP拮抗剂肽及其在治疗C5a或C5a des Arg介导的疾病中的用途。
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