THERAPEUTIC METHODS EMPLOYING PAI-1 INHIBITORS AND TRANSGENIC NON-HUMAN ANIMAL FOR SCREENING CANDIDATE PAI-1 INHIBITORS

摘要

A method of treating a warm-blooded vertebrate animal having a medical condition in need of treatment with a composition that exhibits PAI-I inhibition activity is disclosed. A transgenic non-human animal having incorporated into its genome a PAI-I gene encoding a biologically active PAI-I polypeptide is also disclosed, as is a PAI-I transgene construct encoding a biologically active PAI 1 polypeptide (Figure 1) useful for preparing the transgenic non-human animal. A method of testing a candidate composition for PAI-I inhibition activity using the same transgenic non-human animal is also disclosed.