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METHODS FOR MODULATING A WNK I SOFORM PROTEIN KINASE ACTIVITY
METHODS FOR MODULATING A WNK I SOFORM PROTEIN KINASE ACTIVITY
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机译:调节WNK I蛋白激酶活性的方法
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摘要
A method for identifying a compound expected to be useful in modulating a WNK (With No Lysine Kinase) isoform protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates the protein kinase activity of a WNK isoform polypeptide on the substrate SPAK (STE20/SPS1- related Proline- Alanine-rich Kinase) or OSRl (Oxidative Stress Response kinase-1) and (2) selecting a compound which modulates the said WNK isoform polypeptide protein kinase activity. Such a compound may be useful as an antihypertensive agent or for the treatment of, for example, Gordon's syndrome.
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