NON-HUMAN PRIMATE EMBRYONIC STEM AND GERM CELLS: METHODS OF USE AND METHODS OF MAKING SAME

摘要

The present invention provides a non-human primate (nhp) pluripotential embryonic stem (ES) cell, which can be used in several ways as described herein, including to generate chimeric primate embryos. The invention further provides methods to determine the differentiation status of an embryonic cell by comparing its transcriptional patterns with those of ES cells at particular stages of differentiation. The invention further provides a non-human primate embryonic germ (EG) cell which can also be used in several ways, including administering the differentiated EG cell line to a patient to treat a number of diseases. Also provided are methods of generating nhp ES cell + primate embryo chimeras, and methods of deriving EG cells.