MULTILAYER SPHEROIDS WITH ANTI-MALARIA ACTION AND WITH AN ARTESUNATE-CONTAINING LAYER

摘要

The anti-malaria multilayer spheroids (1) of the invention include at least two layers (3, 4) each containing a different active principle, one of them being artesunate. The second active principle is preferably another anti-malaria compound, in particular lumefantrine, amodiaquine, halofantrine, piperaquine, primaquine, chloroquine or mefloquine or an antibiotic, anti-tuberculosis or anti-parasitic compound. For a quick release, the artesunate is preferably contained in the outer layer of the spheroids. Several methods for making such spheroids are also contemplated. The invention is particularly useful in medicine, in particular for treating malaria.