THERAPEUTIC EFFECTS OF BRYOSTATINS, BRYOLOGS, AND OTHER RELATED SUBSTANCES ON HEAD TRAUMA-INDUCED MEMORY IMPAIRMENT AND TRAUMATIC BRAIN INJURY

摘要

The invention provides for the use of protein kinase activators or boosters of nerve growth factor (NGF); brain-derived neurotrophic factor (BDNF) or other neurotrophic factors to treat traumatic brain injury. Specifically, the present invention provides methods of treating traumatic brain injury comprising the steps of identifying a subject having suffered a traumatic brain injury and administering to said subject an amount of a pharmaceutical composition comprising a protein kinase C (PKC) activator or 4-methylcatechol acetic acid (MCBA) and a pharmaceutically acceptable carrier effective to treat at least one symptom of traumatic brain injury.