MATERIALS AND METHODS FOR MODULATING PROTECTIVE PATHWAYS IN EPITHELIAL CELLS

摘要

The invention provides methods for identifying modulators of an activity of a charged oligopeptide transport molecule of a eukaryotic host cell useful in prophylactic and therapeutic treatments of microbial pathogens, such as virulent intestinal bacteria. In related aspects, the invention provides methods for modulating the activity of Heat Shock Protein 27, Akt, p38 MAP Kinase and/or Ragl.