A method for pharmacokinetic analysis, including: receiving time-series medical image data of a patient introduced with a contrast agent (505); identifying a reference region in the medical image data (510); identifying a plurality of points of interest in the medical image data (515); measuring an intensity of voxels in the reference region (520); and for each point of interest, measure an intensity of voxels therein (525), use the measured reference region and point of interest intensities to obtain an expression relating the point of interest's voxel concentration to that of the reference region (530), wherein the expression is a five-parameter nonlinear model with no reference to an arterial input function; and obtain values for each of the five-parameters by solving the expression (535) and use the obtained values to determine whether the point of interest is malignant (540). (FIG. 5)
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