PHARMACEUTICAL COMPOSITION OF ARTEMISIA EXTRACT USING GASTRO-RETENTIVE DRUG DELIVERY SYSTEM AND ITS ORAL SUSTAINED RELEASE FORMULATION

摘要

There is provided a pharmaceutical composition comprising an extract of Artermisia sp. (Artemisia asiatica, A. mongolica, A. princeps, A. argyi) using a gastro-retentive drug delivery system (GRDDS), and an oral sustained-release formulation using the same. The oral sustained-release formulation comprising an Artemisia extract according to one exemplary embodiment of the present invention may be useful to enhance an absorption rate of a drug in the gastrointestines by allowing the drug to maintain a floating state in the digestive juice or body fluid when the oral sustained-release formulation is administered into a human body, and to improve a therapeutic effect of the drug by slowly releasing the drug to increase a topical reaction of Artermisia asiatica Nakai while retaining the drug in the stomach and intestines for an extended time.