QUINAZOLINONE DERIVATIVE, AND PROPHYLACTIC OR THERAPEUTIC AGENT FOR CORNEAL/CONJUNCTIVAL DISORDER COMPRISING QUINAZOLINONE DERIVATIVE AS ACTIVE INGREDIENT

摘要

A compound represented by the general formula (I) or a salt thereof exhibits excellent prophylactic and ameliorating effect on an age-related corneal disorder or the like in a pharmacological test using SAMP10, and is therefore useful as a prophylactic or therapeutic agent for a corneal/conjunctival disorder such as dry eye, superficial punctate keratitis and corneal epithelial defect. In the general formula (I), A1-A2 represents a group 1; X represents a group 2 or the like; Y represents a carbon atom or a nitrogen atom; a dashed line represents a single bond or a double bond; L represents a single bond, an alkylene group, a cycloalkenylene group or the like; R1a and R1b independently represent a hydrogen atom, a halogen atom or the like; R2 represents a hydrogen atom or a halogen atom; and R3 represents a hydrogen atom or a halogen atom.