VENEZUELAN EQUINE ENCEPHALITIS REPLICONS EXPRESSING PARAMYXOVIRUS GLYCOPROTEINS AS VACCINE

摘要

The present invention is directed to alphavirus vectored vaccine contructs encoding paramyxovirus proteins that find use in the prevention of respiratory syncytial virus or human metapneumo virus infections. In particular, these vaccines induce cellular and humoral immune responses that inhibit RSV. Also disclosed are improved methods for producing alphavirus vectored paramyxovirus vaccines.