DISTINCT HIV-1 GAG AND ENV EPITOPES OF HLA ALLELES ASSOCIATED WITH DIFFERENTIAL SUSCEPTIBILITY TO HIV-1 INFECTION

摘要

We investigated the peptide binding profile of two HLA class I alleles, A*0101 and B*0702, that are associated with differential outcomes of HIV-1 infection. HLA-A*0101 is significantly associated with HIV-1 resistant women (p=0.016, odds ratio: 1.7, 95% CI:1.1-2.7), while HLA-B*0702 is associated with susceptibility to HIV-1 infection.