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TRANSGENIC SYSTEMS FOR THE MANUFACTURE OF POLY(3-HYDROXY -BUTYRATE -CO -3- HYDROXYHEXANOATE)
TRANSGENIC SYSTEMS FOR THE MANUFACTURE OF POLY(3-HYDROXY -BUTYRATE -CO -3- HYDROXYHEXANOATE)
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机译:制造多羟基(3-羟基-丁酸酯-CO-3-羟基己酸酯)的转基因系统
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摘要
Methods for engineering transgenic organisms that synthesize polyhydroxyalkanoates (PHAs) containing 3-hydroxyhexanoate as comonomer have been developed. These processes are based on genetically engineered bacteria such as Escherichia coli or in plant crops as production systems which include PHA biosynthetic genes from PHA producers integrated into the chromosome. In a preferred embodiment of the method, additional genes are introduced in wild type or transgenic polyhydroxybutyrate (PHB) producers, thereby creating new strains that synthesize 3HH monomers which are incorporated into PHAs. The 3HH monomer preferably is derived in microbial systems using butanol or butyrate as feedstocks, which are precursors of 3-hydroxyhexanoyl-CoA. Pathways for in vivo production of butyrol-CoA specifically encompassing butyryl-CoA dehydrogenase activity are provided.
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