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T-cell therapeutics for transmissible spongiform encephalopathy and method for the manufacture of non-infective blood products and tissue derived products
T-cell therapeutics for transmissible spongiform encephalopathy and method for the manufacture of non-infective blood products and tissue derived products
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机译:用于传染性海绵状脑病的T细胞疗法以及非感染性血液制品和组织衍生制品的制造方法
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摘要
B-cells have been identified as being the crucial carriers of infectivity in the spread of transmissible spongiform encephalopathy within an infected animal. In a second step, B-cells may infect further component of the immune system, e.g. T-cells. Accordingly, the present invention provides B-cell and T-cell specific ligands for the use in diagnostics and therapeutics for transmissible spongiform encephalopathy and povides methods for the manufacture of non-infective blood products and tissue derived products. Thus, the present invention provides medicaments comprising B-cell and/or T-cell depletants, for the treatment of pathologies where the depletion of B-cells and/or T-cells, and more particularly of infective B-cells and/or T-cells is therapeutically effective. IMAGE
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