Dimer of a peptide derived from the C-terminal sequence of human superoxide dismutase facilitating the penetration of a substance into cells and/or cell nuclei

摘要

Amino acid sequences (I) that facilitate penetration of a substance of interest (II) into the inside of a cell and/or its nucleus. (I) can react in vivo with aminoglycans (AG) or can react with AG (sic) and are derived from proteins of human origin. Independent claims are also included for the following: (1) associations of (I) and (II); (2) intracytoplasmic and/or intranuclear transfer vectors consisting of, or containing, at least one (I); (3) eukaryotic cells that contain (I) or the vector of (2) or are transfected with this vector; (4) process for in vitro transfer of (II) into cells; (5) composition (biological, pharmaceutical, cosmetic, nutritional, diagnostic or tracer) containing as active agent a vector of (2) or a cell of (3); (6) diagnostic agent comprising the vector of (2) or the cells of (3); and (7) diagnostic kit containing, in one or more vessels, a predetermined quantity of the composition of (5). ACTIVITY : Antiviral; antibacterial; cytostatic; anti-apoptotic; vasotropic; hemostatic. No supporting data given. MECHANISM OF ACTION : Gene or protein replacement; gene therapy. No supporting data given.