COMPOSITIONS AND METHODS FOR REDUCING MACROVASCULAR COMPLICATIONS IN DIABETIC PATIENTS

摘要

The present invention relates to compositions and methods for reducing or ameliorating macrovascular complications in diabetic patients using C-peptide. The compositions and methods of the present invention are for use in controlling or reducing intimal hyperplasia and for reducing the risk of graft failure in diabetic patients undergoing coronary artery bypass surgery in addition to ameliorating primary atherosclerotic disease in diabetic patients. The invention also includes the use of C-peptide in endothelial cell regeneration/proliferation and for the treatment of conditions resulting in endothelial cell injury.