The present disclosure identifies a new polymorphism in the human p22phox gene promoter. The newly described polymorphism may be useful in methods of diagnosis of a disease and/or condition caused by and/or associated with the p22phox gene, increased lev-els of NADPH oxidase activity or increased production of one or more ROS. In addition, the newly described polymorphism may be useful in determining the susceptibility of a sub-ject to a disease and/or condition caused by and/or associated with the p22phox gene, in-creased levels of NADPH oxidase activity or increased production of one or more ROS.
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