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NOVEL TARGETS AND COMPOSITIONS FOR USE IN DECONTAMINATION, IMMUNOPROPHYLAXIS, AND POST-EXPOSURE THERAPY AGAINST ANTHRAX
NOVEL TARGETS AND COMPOSITIONS FOR USE IN DECONTAMINATION, IMMUNOPROPHYLAXIS, AND POST-EXPOSURE THERAPY AGAINST ANTHRAX
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机译:用于去污,免疫原性和抗炭疽的暴露后治疗的新靶标和组合物
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摘要
The present invention relates to the decontamination of anthrax spores, prophylaxis and treatment of anthrax infections and, more particularly, to compounds that act as specific inhibitors of B. anthracis germination/outgrowth-associated proteins, methods and means for making such inhibitors and their use as pharmaceuticals and/or vaccines. The invention also relates to the prophylaxis and treatment of anthrax infections and, more particularly, to vaccines and compositions that comprise B. anthracis antigens, epitopes, proteins, or nucleic acid molecules, including anthrax protective antigen, anthrax lethal factor, anthrax edema factor and anthrax proteins associated with spore germination and outgrowth, as well as methods and means for making such compositions and their use pharmaceuticals and/or vaccines.
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