PLURIPOTENT GENETICALLY MODIFIED HUMAN STEM CELLS CARRYING REPORTER GENE INSERTED IN CHROMOSOME 12 AT NEWLY IDENTIFIED LOCUS, ENVY

摘要

The present invention provides a genetically modified cell comprising a polynucleotide sequence integrated into the ENVY locus from chromosome 12. The ENVY locus advantageously provides a conduit for the ubiquitous or cell type specific expression of heterologous genes in human stem cells.