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NANOSCALE NEUROMODULATING PLATFORM FOR RETINA NEURON ACTIVATION APPARATUS AND METHOD

机译:用于视网膜神经元活化装置的纳米尺度神经调节平台和方法

摘要

Postsynaptic membrance receptor proteins of retinal neurons proximal to the rods and cones mediate the transmission of visual signals at multiple types of chemical synapses in the normally functioning retina, and there is reason to believe that these proximal retinal neurons in certain cases remain functional despite the disease-induced loss of rod and cone visual signaling. The invention is a nanoscale molecular structure that can selectively attach to the extracellular face of specific membrane receptors of post-photoreceptor retinal neurons and, by modulating the postsynaptic receptor's activity in response to light, restore visual signaling in retina damaged by photoreceptor degenerative disease.
机译:视杆和视锥附近的视网膜神经元的突触后膜受体蛋白介导正常运作的视网膜中多种化学突触的视觉信号传递,因此有理由相信,尽管存在这种疾病,但在某些情况下,这些近端视网膜神经元仍保持功能引起的视杆和视锥信号的丢失。本发明是一种纳米级分子结构,其可以选择性地附着于光感受器后视网膜神经元的特定膜受体的细胞外表面,并且通过响应光来调节突触后受体的活性,恢复受光感受器退化性疾病破坏的视网膜中的视觉信号。

著录项

  • 公开/公告号EP1889063A4

    专利类型

  • 公开/公告日2009-06-03

    原文格式PDF

  • 申请/专利权人 UNIVERSITY OF ILLINOIS AT CHICAGO;

    申请/专利号EP20060824723

  • 发明设计人 PEPPERBERG DAVID R.;

    申请日2006-04-28

  • 分类号G01N33/68;C12N5/06;G01N33/94;

  • 国家 EP

  • 入库时间 2022-08-21 19:17:23

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