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MODULATION OF EGFR SIGNALLING BY MODULATION OF SPHINGOSINE KINASE SIGNALLING
MODULATION OF EGFR SIGNALLING BY MODULATION OF SPHINGOSINE KINASE SIGNALLING
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机译:通过调节鞘氨醇激酶信号转导来调节EGFR信号转导
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摘要
The present invention relates generally to a method of modulating EGFR-mediated cellular functional activity and agents useful for same. More particularly, the present invention relates to a method of modulating agonist induced EGFR-mediated cellular proliferation by modulating upstream intracellular sphingosine kinase signalling. The method of the invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant EGFR-mediated cellular functioning, in particular aberrant EGFR-mediated cellular proliferation.
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