METHOD FOR THE DETECTION AND PREDICTION OF OBESITY-RELATED RENAL DISEASE

摘要

A method for the early identification and prediction of renal damage in a subject with obesity comprises contacting a urine sample from the subject with a capture molecule for a biomarker specific to a region of the kidney and which biomarker is released from said region when there is damage to said region, an elevated level of said biomarker relative to a normal level being indicative and predictive of renal damage. The biomarkers include αGST, πGST and Collagen IV. The method enables the detection of renal injury in obese patients who otherwise have been regarded as having normal renal function as measured by serum creatinine or estimated glomerular filtration rate, thereby facilitating early intervention in the treatment of such patients.